Dr. Stephen Hyde

Biography

Stephen Hyde is a Professor at the Radcliffe Department of Medicine, University of Oxford, with a focus on molecular therapy, gene therapy, and lung diseases. He co-directs the Gene Medicine Research Group, where his research emphasizes the application of gene therapy technologies for therapeutic interventions in human diseases. His post-doctoral research at Oxford demonstrated successful gene transfer to correct Cystic Fibrosis defects in transgenic mice. He has led extensive pre-clinical and clinical programs in gene therapy and has been a founding principal investigator of the UK Cystic Fibrosis Gene Therapy Consortium. Under his leadership, the Gene Medicine Research Group has evaluated four clinical trials of gene therapy, with a recent phase IIb study involving 136 participants showing improvements in lung function through gene therapy. His current research includes the development of CpG-free non-viral gene transfer formulations and advanced adeno-associated virus and lentiviral gene transfer vectors for efficient lung gene transfer. He possesses particular expertise in designing viral and non-viral gene therapy vectors, characterizing aerosol properties for lung delivery, and regulatory compliance in vector production. Additionally, he serves as a specialist advisor on clinical safety for gene therapy vectors within the Department of Health’s Gene Therapy Advisory Committee.

Research Interests