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Stephen Wilkie is currently investigating the role of serine metabolism in leukemic stem cells both in vivo and in vitro, focusing on genetic, pharmaceutical, and dietary interventions. His research employs metabolomic analysis and high-resolution respirometry, alongside large single-cell RNA sequencing datasets, to uncover metabolic vulnerabilities that can inform therapeutic strategies targeting carbon metabolism. He has undergone postdoctoral training in the Larsson lab, concentrating on mitochondrial biology and its impact on metabolism in lung adenocarcinoma models. His work involved generating new mouse models to examine the effect of modulating mitochondrial biology on tumor growth, utilizing cell culture models to elucidate cell-autonomous mechanisms of tumor aggressivity. Through his research, he has contributed to a greater understanding of the dynamics of mitochondria in lung cancers.
Paul O'Gorman Leukaemia Research Centre • Glasgow, Scotland, United Kingdom