Dr. Steven Abramson

Biography

Steven Abramson is the Chair of the Department of Medicine and holds the Frederick H. King Professorship in Internal Medicine at NYU Grossman School of Medicine. His research focuses on the roles of cytokines, growth factors, and extracellular matrix proteins in chondrocyte signaling pathways and the molecular mechanisms that regulate chondrocyte and bone cell biology. His laboratory studies the cellular and molecular mechanisms underlying chondrocyte differentiation and maturation, utilizing global gene expression techniques such as microarray analysis to explore gene expression changes in osteoarthritis cartilage versus non-arthritic cartilage. Professor Abramson's interests also include the characterization of promoters of dysregulated genes, employing software to analyze transcription factors' influence on genes. He has discovered that osteoarthritis chondrocytes undergo phenotypic modulation to a hypertrophic state typical of degradative chondrocytes, thus suggesting a critical role in disease progression. His current investigations also delve into epigenetic changes and microRNA expression related to the transcriptional and translational regulation of genes that affect chondrocytic phenotype.

Research Interests

Experience