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Steven M. Albelda, MD, is a Professor in the Department of Medicine at the Perelman School of Medicine, University of Pennsylvania. His research expertise includes immuno-gene therapy and thoracic malignancies, particularly lung cancer, which remains a leading cause of cancer deaths in the United States. Dr. Albelda’s work focuses on the design of new treatment strategies for lung cancer and mesothelioma by leveraging advancements in molecular biology, immunotherapy, and gene therapy. He conducts preclinical studies using animal models and human tumor samples, along with clinical trials, aimed at understanding and manipulating the tumor microenvironment. This includes investigating the immunosuppressive roles of white blood cells and fibroblasts, as well as exploring novel approaches using COX-2 inhibitors and TGFbeta inhibitors to enhance the efficacy of immunotherapy. Additionally, he is involved in clinical trials utilizing adenoviral vectors expressing immune-activators for mesothelioma patients. His laboratory’s work is primarily funded by the National Cancer Institute.
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