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Steven Fluharty, Professor at the Department of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania, specializes in the pharmacological science of angiotensin II (AngII). His research focuses on the cellular and molecular mechanisms of AngII action within the brain. He employs techniques such as radioligand binding, quantitative autoradiography, and immunocytochemistry to study the localization of AngII receptors in the central nervous system. Through biochemical techniques, his work aims to elucidate the coupling of these receptors to ion channels and intracellular effector mechanisms involving adenylyl cyclase and nitric oxide synthase. Additionally, he has been involved in the purification of neuronal AngII receptors, the development of receptor-directed antibodies, and the cloning of genes encoding for these receptors. His contributions are significant to the understanding of neuropeptide receptor gene expression and signal transduction, incorporating both behavioral measurements and advanced molecular techniques in his approaches.
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