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Steven P. Smith is a professor at Queen's University in the School of Medicine, specializing in Biomedical Molecular Sciences. His research program focuses on structural biology, utilizing techniques such as nuclear magnetic resonance (NMR), X-ray crystallography, and small-angle X-ray scattering. Smith's work aims to identify molecular determinants that regulate the assembly and function of macromolecular complexes. His current research includes studying mucin-degrading enzyme complexes associated with the opportunistic pathogen Clostridium perfringens, analyzing the assembly and higher-order structure of cellulosomes, which are efficient lignocellulose-degrading bacterial enzyme complexes, and investigating the molecular determinants involved in E2A transcription factor-target protein interactions that regulate lymphopoiesis in acute lymphoblastic leukemia. Smith has published numerous papers in recognized journals and has contributed to advancing the understanding of these complex biological systems.
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