Dr. Steven Tannenbaum

Biography

Steven R. Tannenbaum is the Underwood-Prescott Professor of Biological Engineering and Chemistry at the Massachusetts Institute of Technology (MIT). His research laboratory focuses on the formation, distribution, and metabolism of nitrate, nitrite, and N-nitroso compounds. Significant work from Tannenbaum's lab has emphasized the discovery of endogenous nitrogen oxides leading to the identification of nitric oxide as a critical biological molecule. Current investigations in the laboratory explore the pathophysiological consequences of nitric oxide oxidation products, including cell-mediated nitrosation and free-radical reactions that can cause DNA damage with genotoxic consequences. This research is particularly vital in understanding inflammatory states and infections that increase cancer risk. Tannenbaum’s group is also engaged in developing methodologies to inhibit reactions with antioxidants to provide protection against oxidative stress. A key focus of the lab is tissue engineering and drug development, with innovative approaches for assessing drug metabolism and chemical toxicity through unique micro tissue arrangements combined with mass spectrometry and optical sensors. The lab aims to develop in vitro systems for detecting toxins and enhancing drug metabolism assessment using state-of-the-art mass spectrometry techniques.

Research Interests

Experience