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Dr. Stuart N. Isaacs is an Associate Professor at the Perelman School of Medicine at the University of Pennsylvania, specializing in Infectious Diseases. He is actively engaged in research focused on viral pathogenesis, specifically exploring the mechanisms by which viruses evade the host immune response. His laboratory utilizes poxviruses as model systems to study viral proteins that are implicated in pathogenesis and dissemination. The research notably includes investigating the use of recombinant vaccinia viruses as vaccine vectors and counter-bioterrorism measures related to smallpox and monkeypox. Dr. Isaacs has also been a project leader for NIH-funded initiatives aimed at developing safer vaccines against smallpox and related therapies. His work extends to the study of molluscum contagiosum, a poxvirus affecting skin infections, particularly in children. Furthermore, he serves as the Local Site investigator for a VA-wide cooperative studies program focused on COVID-19 epidemiology and clinical characteristics. Dr. Isaacs' contributions to the field include both the elucidation of immune evasion strategies used by viruses and the advancement of vaccine development.
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