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Stuart Orkin is the David G. Nathan Distinguished Professor of Pediatrics at Harvard University. His research interests encompass various aspects of hematopoiesis, stem cell biology, and the transcriptional control of developmental potency. He has developed a significant understanding of the programmed, cell-specific patterns of gene expression and has contributed substantially to the field of blood cell development. His ongoing projects focus on epigenetic regulation of hematopoietic stem cells, the genetic factors involved in early childhood leukemia using human embryonic stem cells and induced pluripotent stem cells, and the mechanisms controlling fetal hemoglobin reactivation in adults. He utilizes diverse methodologies including conditional gene targeting and proteomics, contributing to the characterization of transcription factors involved in blood cell development and the abnormalities that lead to malignancies. His work continues to provide crucial insights into the developmental pathways and potentials of various blood lineages.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).