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Subhojit Roy is a Professor in the Department of Pathology at UC San Diego. His research focuses on the mechanisms by which neurons transport molecules and the role of proteins such as alpha-synuclein in synaptic function and neurodegenerative diseases. He is particularly interested in manipulating trafficking pathways as potential therapeutics for these diseases using gene editing technologies like CRISPR. His work includes diverse research activities funded by the NIH, such as investigating the pathophysiological roles of alpha-synuclein at synapses and the development of nanoplatforms for targeted delivery of CRISPR/Cas9 ribonucleoproteins in vivo. Subhojit has co-directed projects on identifying genetic modifiers of amyloid precursor protein and BACE-1 interactions, aiming to understand the molecular determinants of axonal actin assemblies. His findings can have significant implications for treating neurodegenerative conditions, especially through innovative therapeutic strategies involving genetic engineering.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).