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The laboratory studies the genetic basis by which form and structure are regulated during embryonic development, producing exquisite morphology in vertebrate embryos. We combine classic methods of experimental embryology with modern molecular, imaging, genetic, and genomic techniques to interrogate and test gene function. Our evolutionary work addresses questions of morphological, behavioral, and metabolic evolution across a variety of species using developmental genetic approaches. We focus on projects using chick and mouse systems to address a range of questions related to limb development, skeletal morphogenesis, and the physical forces involved in gut development. Among our current efforts is the investigation of cave fish evolution, where we examine genetic bases for human-specific traits by comparing fish adapted to life in caves with their free-swimming river cousins. This work aims to uncover the genetic underpinnings behind unusual skin features and thermoregulation adaptations.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).