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Tae-Hee Lee is a Professor of Chemistry at the Eberly College of Science. His research focuses on single molecule biophysics, particularly involving nucleosomes, chromatin, and gene regulation. By utilizing cutting-edge methods such as single-molecule fluorescence resonance energy transfer (smFRET) and optical super-resolution techniques, Lee investigates the dynamics of biological macromolecular complexes, essential to understanding their function and behavior. His interdisciplinary research program integrates aspects of physical chemistry, analytical chemistry, biochemistry, and cellular biology, enabling a comprehensive view of how nucleosomes and chromatin regulate genome transactions. Lee has contributed significantly to various high-impact publications throughout his career, including studies on the conformation dynamics of single-stranded DNA and the role of histone modifications in nucleosomal interactions. His ongoing work explores the mechanisms by which chromatin remodeling enzymes affect nucleosome dynamics, providing insights into fundamental processes governing gene expression and cellular function.
The Pennsylvania State University • University Park, PA
Professor in the Department of Chemistry focusing on single molecule biophysics and chromatin dynamics.
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