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Tai-ping Sun is the John Carlisle Kilgo Distinguished Professor in the Department of Biology at Duke University. His research investigates the pivotal roles of the diterpenoid phytohormone gibberellin (GA) in regulating growth and development in higher plants. His laboratory uses a variety of approaches, notably with the model organism Arabidopsis, to elucidate the regulatory mechanisms underlying GA biosynthesis and signaling pathways. Major breakthroughs include identifying nuclear transcriptional regulators known as DELLA proteins, which act as growth repressors by inhibiting various aspects of GA responses. His research shows that the binding of GA to the nuclear receptor GID1 enhances its interaction with DELLA, leading to rapid proteolysis of DELLA proteins via the ubiquitin-proteasome pathway. Moreover, his team has uncovered the integration of internal developmental signals and environmental stresses in plant growth regulation. Recent studies focus on the role of post-translational modifications, including O-linked glycosylation, in modulating DELLA activity and regulating plant developmental processes.
Department of Biomedical Engineering (MS program)