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Tal Nuriel is an Assistant Professor at Columbia University in the City of New York, specializing in the fields of pathology and cell biology within the Taub Institute. His primary research focus investigates the physiological pathological biology of apolipoprotein E ε4 (APOE4), which is recognized as the primary genetic risk factor for late-onset Alzheimer's disease (AD). Nuriel's work has led to significant discoveries regarding how APOE4 modulates neuronal activity, alters endosomal-lysosomal processing, and impacts bioenergetic regulation in brain regions vulnerable to AD. His research team is currently engaged in expanding these findings through a variety of advanced methodologies, including multi-omics, MRI, and electrophysiology. The ultimate aim of Dr. Nuriel's research is to enhance the understanding of why APOE4 carriers face an increased risk of developing AD, whilst also identifying innovative treatment strategies and therapeutic lifestyle changes to prevent or slow the development of the disease in at-risk populations.
Columbia University • New York, NY
Involved in academic research and teaching in the areas of pathology and cell biology.
Department of Anthropology (GSAS)