Dr. Teresa Wang

Biography

Teresa Wang is the Klaus Bensch Professor of Experimental Pathology, Emerita at Stanford University. Her research primarily focuses on understanding the molecular mechanisms involved in maintaining genome integrity and chromosome replication. She conducts two main research programs: the first investigates the types of mutations in genes that play a critical role in DNA replication, which are the early events in tumorigenesis that lead to the source of genetic instability observed in cancer cells. She employs budding and fission yeast model organisms to identify replication mutators and has introduced similar mutations in homologous genes in human cell lines, studying the physiological effects of these replicative mutators through cytogenetic, cell biological, and biochemical approaches. The second area of her research explores how cells respond to replication stress in order to maintain genome integrity, with specific focus on checkpoint mechanisms that induce tolerance to replication stress, prevent replication fork collapse, and promote replication fork re-start. Knowledge gained from her fission yeast studies is applied to investigate how mammalian cells respond to replication stress.

Research Interests

Courses