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Terry Orr-Weaver is a Professor Emerita at the Massachusetts Institute of Technology (MIT) and an alumna of the Whitehead Institute. As she prepares to close her lab, she reflects on her extensive research into the complex processes involved in development from a fertilized egg to an adult organism. Throughout her career, Orr-Weaver has focused on the intricate regulation of cell division, cell size, and the various transitions that occur as an oocyte develops into an embryo. Her work has involved studying the regulators that lead to cell cycle changes during meiosis and embryonic mitosis, aiming to clarify how coordination is achieved among cell size, tissue layers, and the regulation of DNA replication origins and progression. Her contributions to developmental biology have been influential, and as she retires, her legacy includes important findings that have shaped our understanding of these fundamental processes.