Generate a tailored SOP for Dr. Theodoros Simakou. Improve your application with a focused, well-structured draft.
Theodoros Simakou is a Research Associate in Biomedical Engineering at the University of Glasgow within the School of Infection & Immunity. His research interests lie at the intersection of immunology and mechanobiology, primarily focusing on the roles of the mechanosensory channel PIEZO1 in the differentiation and phenotypes of macrophages, especially in the dynamic mechanical environments of joints. Since starting his PhD in 2017, he has committed to understanding how mechanical stimuli in healthy and pathological tissues influence cellular responses, particularly in synovial macrophages. His work utilizes advanced cell culture techniques, including 2D and 3D co-cultures, CRISPR-Cas9 gene editing, and single-cell transcriptomics, to unravel the mechanisms of mechanotransduction and its implications in autoimmune diseases like Rheumatoid Arthritis. Beyond research, he is also dedicated to teaching and supervising undergraduate and postgraduate immunology students.
University of Glasgow • Glasgow, Scotland, UK
Conducting research on the roles of mechanosensory channels in macrophage differentiation and the impact of mechanical stimuli on joint health.