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Thivanka Muthumalage's current research focuses on inhalation toxicity and immunotoxicity from combustible tobacco and emerging tobacco products, particularly flavored electronic cigarettes. His lab employs advanced in vitro, ex vivo, and in vivo pulmonary exposure disease models to study lung injury responses associated with acute lung injury and acute respiratory distress syndrome. Muthumalage investigates the underlying mechanisms of these responses, emphasizing the immunometabolic changes in immune cells within the lung and the effects of environmental toxicants on both healthy and pre-existing disease conditions such as asthma, COPD, and fibrosis. His key research areas include examining DNA damage, telomere dysfunction, immunometabolism, and the exposome's role in pulmonary disease pathogenesis.
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