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Associate Professor in Microbiology and Immunology, Thomas Clarke focuses on the relationship between the commensal microbiota and immune function. His research explores how environmentally exposed surfaces that humans colonize harbor a vast number of foreign microbes, which play a crucial role in regulating both mucosal and systemic immune responses. Disruptions in this relationship are linked to a wide variety of diseases, including immune dysfunctions and chronic inflammatory conditions, as well as autoimmunity and increased susceptibility to infections from bacteria, viruses, and parasites. One of the key areas of his work seeks to understand the mechanistic basis of how the commensal microbiota influences systemic immunity, especially in the context of bacterial infections and vaccinations. His overarching research theme is to investigate how changes in the composition of the microbiota can disrupt immune responses and affect overall health.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.