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Thomas DeRaedt is an Assistant Professor in the Department of Pediatrics at the University of Pennsylvania's Perelman School of Medicine. His research focuses on understanding the mechanisms behind pediatric High Grade Gliomas (pHGG) and the development of novel therapies for this devastating disease. His lab aims to elucidate pathways and interactions that drive pHGG through the molecular analysis of tumor samples, cellular studies, and the creation of advanced mouse models. DeRaedt's work has led to insights driving multiple clinical trials. He investigates the RAS signaling pathway, a significant oncogenic pathway in cancer, and explores epigenetic mutations that co-occur with RAS pathway mutations. DeRaedt strives to find new therapeutic approaches, including cellular immunotherapies, to improve treatment outcomes for pediatric brain tumors. He is actively developing tools for functional validation of new cancer drivers and testing immunotherapeutic strategies in pre-clinical models. His innovative efforts include creating a cellular immunotherapy delivery system to circumvent challenges unique to brain tumors, showing promise in preclinical trials.
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