Dr. Thomas Graeber

Biography

Thomas Graeber is a faculty member in the Department of Molecular and Medical Pharmacology at the University of California, Los Angeles (UCLA), and serves as the director of the UCLA Metabolomics Center. He is an established investigator with the Melanoma Research Alliance and a research scholar with the American Cancer Society. His academic background encompasses physics, cancer biology, signal transduction, metabolism, computational biology, proteomics, and metabolomics. His research focuses on developing experimental and computational approaches to study cancer signaling and metabolism from a systems perspective. His work has significantly contributed to the understanding of hypoxia as a common feature in solid tumors, which influences p53 protein levels and apoptosis in p53-deficient cells. Additionally, he has developed algorithms to identify potential autocrine signaling loops in cancer, facilitating the analysis of gene expression data. His ongoing research aims to unravel the interactions between cellular signaling and metabolic networks with the goal of identifying therapeutic targets. He emphasizes the need for interdisciplinary collaboration and utilizes mass spectrometry-based profiling to collect and analyze high-dimensional data from patient samples, aiming to translate findings into clinical applications.

Research Interests