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Thomas Hinds is a Research Associate Professor Emeritus at the University of Washington in the Department of Pharmacology. His research focuses on Drug Discovery and Precision Medicine, specifically involving intracellular signaling and protein structure. Hinds's expertise lies in the precise quantitative measurement of protein-ligand and protein-protein interactions using modern biophysical and biochemical methods. In the Zheng laboratory, he trains and supports junior laboratory members, mentoring them to understand and implement biophysical biochemical techniques crucial for quantifying these biological interactions. His work emphasizes the importance of rigor and reproducibility in advancing science and essential biomedical research. Hinds develops biochemical enzymatic assays to determine the activities of multi-subunit cullin-RING ubiquitin ligases, which are vital in sensing cellular signals and ubiquitinating specific substrates, including the reverse reaction catalyzed by deubiquitinating enzymes (DUBs).
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