Dr. Thomas Lanyon Hogg

Biography

Thomas Lanyon-Hogg is a Wellcome Trust Career Development Fellow at the University of Oxford, in the Department of Pharmacology. His research focuses on drug discovery with specific emphasis on medicinal chemistry and chemical biology. His work involves the synthesis and development of biologically active small molecules, particularly identifying new inhibitors through various screening approaches. He utilizes rational computational guidance to design improved molecules, testing their efficacy in biochemical and cellular settings. Current projects include the development of molecules to reverse antibiotic resistance, inhibitors of the Hedgehog signaling pathway in cancer, and modulators of protease activity related to cancer development. In addition, his chemical biology research leverages chemical methodologies using small molecules to probe critical biological questions, including organic synthesis and biorthogonal 'click' chemistry, as well as mass spectrometry-based proteomic analyses.

Research Interests