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Thomas Pulinilkunnil is a Professor at Dalhousie University's Department of Biochemistry and Molecular Biology. His research focuses on metabolic regulation, particularly in the context of heart disease and cancer. Pulinilkunnil's work includes exploring autophagy, nutrient regulation, and lysosomal function, particularly how these processes relate to heart disease and cancer metabolism. He employs a multispecies approach, utilizing models such as rodents, yeast, and zebrafish to investigate the impact of nutrients like glucose and amino acids on lysosomal function and autophagy. His lab is engaged in understanding how aberrations in lysosomal function affect mitochondrial metabolism and energetic profiles in cardiovascular diseases. Pulinilkunnil also investigates the role of glycosylation in health and disease, aiming to elucidate the molecular pathways that lead to congenital disorders of glycosylation. His research contributions highlight the critical relationships between metabolic pathways, cellular signaling, and disease outcomes, particularly in the realms of obesity, diabetes, and cancer.