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Thomas Roberts is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard University. His research focuses on kinases and kinase inhibitors, particularly in the context of cancer. The Roberts lab utilizes a variety of model systems and approaches, including systems biology and mouse genetics, to study the roles of kinases and phosphatases. Notably, he has adapted telomerase-immortalized breast and prostate epithelial cells to investigate mechanisms of kinase inhibitor resistance. With years of experience working at Novartis in the development of kinase inhibitors, Roberts's current projects include a detailed examination of the PI3 kinase pathway. He has generated conditional mouse knock-out models for key p110 isoforms, as well as transgenic mice expressing activated alleles of p110s, to explore their roles in development, aging, and cancer. Recently, his work has focused on understanding the impact of PTEN loss on the activation of the p110 beta isoform of PI3K, aiming to use this information to develop improved therapies for PTEN null human tumors.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).