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Dr. Wubben is a vitreoretinal surgeon who provides medical and surgical care to adult and pediatric patients with a multitude of retinal degenerative diseases. His clinic performs subretinal gene therapy as part of an inherited retinal disease group at the University of Michigan. As a clinician-scientist, his ultimate goal is to identify viable human therapies that reduce morbidity and improve vision for those affected by retinal disorders. The Wubben laboratory focuses on the intersection of retinal cell metabolism and retinal disease, understanding metabolic pathways that support retinal cell function and survival in order to develop novel therapeutic paradigms to prevent vision loss. Utilizing a multi-disciplinary approach with techniques in chemical biology, biochemistry, and cell molecular biology, they employ mass spectrometry-based metabolomics to unravel the crucial metabolic pathways for photoreceptors and retinal pigment epithelium (RPE) across multiple experimental systems, including rodent and rabbit models of macular degeneration, inherited retinal disease, retinal detachment, and proliferative vitreoretinopathy (PVR). Insights obtained from these studies inform the design of targeted small molecule therapeutics and gene therapies.
Admission for Biological Chemistry, Cellular and Molecular Biology, Human Genetics, Microbiology and Immunology, Pharmacology, Molecular and Integrative Physiology, Cancer Biology, and Neuroscience is primary handled through the PIBS (Program in Biomedical Sciences) gateway.