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Tiago Dias da Costa is an Associate Professor in the Department of Life Sciences at Imperial College London. His research focuses on understanding the structural basis of bacterial double-membrane spanning molecular machines and their implications in bacterial pathogenesis, particularly in the context of antibiotic resistance. His lab employs a multidisciplinary approach combining bacterial genetics, biochemistry of membrane proteins, and advanced single particle cryo-electron microscopy (Cryo-EM) to unravel the mechanisms of conjugal transfer and the functioning of type IV secretion systems (T4SS) that play a critical role in horizontal gene transfer among bacteria. Dr. Costa's work addresses the dynamics of antimicrobial resistance (AMR) gene propagation through mobile genetic elements, highlighting the significance of these processes in bacterial evolution and adaptability within environments such as the gut microbiome. His notable contributions include elucidating structural aspects of the F-pilus and the outer-membrane core complex, providing insights essential for combating AMR through potential therapeutic strategies.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.