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Tigran Chalikian’s research program focuses on the biophysical properties of biological molecules and complexes. He investigates the physico-chemical forces that govern inter- and intramolecular interactions in biopolymers, proteins, and nucleic acids. His work aims to understand how molecular forces stabilize structures and govern the interactions of specific biopolymers with drug targets, particularly in relation to pathologies. The changes resulting from genetic mutations can alter protein structures, which are affected by environmental factors like pH, temperature, and ion concentrations. By understanding the physical basis of protein folding, misfolding, and the interaction of proteins with ligands and nucleic acids, Chalikian aims to develop effective treatment strategies for diseases. His research operates at the intersection of physics, chemistry, and biology to uncover the biophysical principles that govern interactions among complex biological structures, gaining vital molecular insights into cellular events such as enzymatic catalysis and gene transcription. His lab employs a variety of optical techniques and thermodynamic measurements to quantitatively characterize biological interactions, including spectrophotometry, circular dichroism, and fluorescence spectroscopy.
Department of Sociology