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Timothée Lionnet is an Assistant Professor at NYU Tandon School of Engineering, focusing on the intersection of biophysics and cellular biology. He develops novel imaging technologies to understand the fundamental principles of gene expression. Holding a PhD from Ecole Normale Supérieure in France, he designed and built a highly sensitive single-molecule magnetic tweezers microscope. This system enabled the discovery that DNA double helix stretches are overwound, a property that has profound implications for DNA sequence recognition. He uncovered new principles that drive the mechanochemistry of DNA helicases while working in Rob Singer's laboratory at A. Einstein College of Medicine. Here, he advanced the development of single-molecule technologies for studying gene expression in live cells and animals. Lionnet became a Project Scientist at the Transcription Imaging Consortium at Janelia Research Campus, where he led a research group working on fluorescence technologies to explore the transcription mechanisms at the single-molecule level. Since joining the Institute for Systems Genetics at NYU School of Medicine in 2017, he has aimed to develop cutting-edge microscopy techniques to visualize and manipulate individual cells in real time, utilizing unique tools to understand how robust cell fates emerge from random molecular dynamics, particularly in the context of cancer evolution.
Administered by the Department of Electrical and Computer Engineering.