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Todd William Ridky, M.D., Ph.D. is an Associate Professor in the Department of Dermatology at the University of Pennsylvania. His research expertise lies in epithelial biology, gene regulatory control of epidermal homeostasis, epithelial oncogenesis, and tissue models of human malignancy. His lab, the Ridky Lab, employs genetically-defined, engineered epithelial tissues as an experimental platform to study pathways driving human cancer initiation and progression. The lab's focus is on developing experimental human tissue systems from normal primary human cells, creating architecturally faithful native 3-D environments that mimic the human stroma and living stromal cells. These advancements allow for unprecedented experimental complexity and rapidity, facilitating the transformation of normal human tissues into invasive cancer models through defined genetic alterations. Ridky’s work utilizes bioinformatics and systems biology to identify crucial elements that promote cancer and employs genetic and protein-level interventions for developing targeted molecular therapeutics.
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