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Tom Keeley is a researcher in the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. His work focuses on understanding how multicellular organisms sense and respond to changes in oxygenation over a variety of timescales, from seconds to thousands of years. His research examines the adaptation mechanisms that facilitate responses to hypoxic environments, notably through the hypoxia-inducible factor (HIF) transcription factor pathway. Keeley investigates new mechanisms of non-transcriptional oxygen sensing, particularly involving 2-aminoethanethiol dioxygenase (ADO) and its role in regulating G-protein signaling based on cellular oxygen availability. He collaborates closely with other researchers in the field, employing a range of biochemical, molecular, and physiological techniques to study these processes across different biological systems, including cultured cells, isolated tissues, and whole animals.
St. Catherine’s College, Oxford • Oxford, England
Conducting research in medical sciences with a focus on hypoxia research.
Nuffield Department of Medicine • Oxford, England
Worked on novel hypoxia signaling pathways under Professor Sir Peter Ratcliffe.
Department of Politics and International Relations - Higher Level English requirement.