Dr. Tom Maniatis

Biography

Tom Maniatis is the Isidore S. Edelman Professor of Biochemistry at Columbia University, where he has significantly contributed to the field of molecular biology. His pioneering work in gene cloning technology has had a profound impact on basic research and biotechnology. He coauthored the definitive laboratory manual, 'Molecular Cloning', and his research has advanced our understanding of gene regulation, RNA splicing, innate immunity signaling pathways, and neurodegenerative disease mechanisms. Maniatis received his BA and MS degrees from the University of Colorado and his Ph.D. in molecular biology from Vanderbilt University. He conducted postdoctoral studies at Harvard University and held faculty positions at the California Institute of Technology and Harvard University. His recent research focuses on understanding the mechanisms of ALS through a combination of human genetics, stem cell, and animal model approaches. He has developed behavioral assays to characterize the phenotypic consequences of mutations in mouse models, contributing to the understanding of ALS disease progression and the role of neuroinflammation in neurological diseases. Maniatis has been recognized with several awards and is a member of prestigious scientific academies, including the National Academy of Sciences.

Research Interests

Experience

Awards