Dr. Tony Jackson

Biography

Tony Jackson is a researcher at the University of Cambridge within the Department of Biochemistry, focusing on sodium channels as plasma membrane proteins in electrically excitable cells. His work centers on voltage-gated sodium (Nav) channels which initiate action potentials and serve as major pharmacological targets implicated in various health conditions including heart disease, epilepsy, and chronic pain. Jackson's research investigates the role of the beta 3-subunit in regulating Nav channels, with studies indicating that the deletion of the gene for this subunit is associated with cardiac arrhythmias. He employs various techniques such as electrophysiology, site-directed mutagenesis, and single-chain antibody technology to study beta 3-subunit interactions. Jackson is actively involved in collaborative projects developing a quantitative proteomics method known as 'Selective Proteomic Proximity Labelling Assay Using Tyramide' (SPPLAT), to identify molecular near-neighbors of selected plasma membrane proteins. His research includes understanding the molecular organization of Nav channels in neuronal and cardiomyocyte plasma membranes to better address health issues. Jackson's key publications span a range of journals, significantly contributing to the field of biomolecular sciences.

Research Interests