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Trevor M. Penning is a Professor at the Perelman School of Medicine, University of Pennsylvania, working in the Department of Systems Pharmacology and Translational Therapeutics. He completed his Bachelor of Science in Physiology Biochemistry (First Class Honors) in 1972 and received his Ph.D. in Biochemistry in 1976, both from Southampton University, UK. His research focuses on steroid hormone transforming aldo-keto reductases (AKRs) and their role in metabolic activation of chemical carcinogens. His work has implications for the therapeutic targeting of steroid hormone action through enzyme inhibitors, particularly in the context of castrate-resistant prostate cancer. Penning's laboratory employs various techniques, including x-ray crystallography, transfection studies, and gene editing, to explore the structure and function of enzymes involved in critical biochemical pathways.
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