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Trista Elizabeth North is a Professor in the Department of Pediatrics whose research focuses on hematopoietic stem cells (HSCs) and their regulation during development and disease. Her laboratory employs genetic techniques and chemical biology approaches in zebrafish to identify and characterize the pathways that control HSC induction and expansion. The laboratory's work has significant implications in understanding the conservation of these regulatory pathways and their translational applications, including murine and human assays to analyze HSC functions. They have pioneered a cross-species functional validation methodology that has led to advancements such as the FDA approval for the investigational use of Prostaglandin E2, identified through studies on zebrafish. North’s lab is currently investigating the developmental aspects of hemato-vascular biology, focusing on the regulation of hemogenic endothelium, the influence of environmental factors on hematopoiesis, and the implications of these findings for the onset of blood disorders. The trainees in her lab have achieved independent funding and have made significant contributions to conferences and the academic community, transitioning to leadership roles in academia and industry.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).