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Tso-Pang Yao is a Professor at Duke University, focusing on Pharmacology and Cancer Biology, and also serves as an Assistant Professor in Radiation Oncology. He is a member of the Duke Cancer Institute. With a Ph.D. from the University of California, San Diego, his research encompasses regulatory functions of protein acetylation and its implications in cell signaling and human diseases. His laboratory investigates protein deacetylases, particularly HDACs, elucidating their roles in gene transcription and therapeutic applications of HDAC inhibitors in cancer treatment. Yao's current projects involve quality control autophagy mechanisms, mitochondrial biology and cancer metabolism, and the role of HDACs in muscle remodeling associated with neuromuscular diseases. His studies employ various cellular models to unravel the therapeutic potential of HDAC6 in neurodegenerative and metabolic disorders. Yao has authored several significant publications in prominent journals, contributing to the understanding of histone deacetylases and their biological functions. His work continues to advance insights into the intersection of aging, cellular quality control, and disease pathology.
Department of Biomedical Engineering (MS program)