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Ulrich Krull is a Professor Emeritus in the Department of Chemistry at the University of Toronto. His research focuses on analytical chemistry, particularly in the development of luminescence nanoparticles that facilitate selective interactions on surface nanoparticles through resonance energy transfer. His work involves the use of fluorescent labels to transduce binding interactions, with selectivity achieved by utilizing immobilized biomolecules for interaction with proteins, peptides, and nucleic acid sequences. Krull has been at the forefront of multiplexed solid-phase bioassays and paper-based platforms that contribute to rapid detection technologies for markers of pathogens and genetically-based diseases. He explores innovative approaches such as microfluidics for sample manipulation and the integration of signal enhancement techniques that enable the use of cell phone cameras and spectrally-selective detectors. Additionally, he investigates photo-controlled intracellular drug release mechanisms where nanoparticles serve as platforms for therapeutic compounds, converting near-infrared excitation light into UV-visible emission that leads to photolytic cleavage and the concurrent release of therapeutic agents. His contributions to the field have been instrumental in advancing medical diagnostics.
Department of Sociology