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Victor Tybulewicz is a Principal Group Leader and Assistant Research Director at the Francis Crick Institute, specializing in immune cell biology and Down syndrome research. He graduated with a BSc from Imperial College London in 1981 and obtained his PhD from the MRC Laboratory of Molecular Biology at Cambridge in 1984. As a postdoctoral fellow at the Whitehead Institute, MIT, he worked under Professor Richard Mulligan, focusing on methods for targeting mouse embryonic stem cells. Returning to the UK in 1991, he established his group at the MRC National Institute for Medical Research (NIMR), using mouse genetics to investigate signal transduction in lymphocytes and the role of signalling molecules in B cell development. His recent studies have concentrated on the kinases SYK and WNK1, as well as the BAFF receptor BAFFR. In 2015, his lab moved to the Francis Crick Institute. In collaboration with Elizabeth Fisher from UCL, he generated a novel Tc1 mouse model that freely segregates a copy of human chromosome 21, leading to insights into Down syndrome phenotypes and congenital heart defects. Tybulewicz is recognized as a Member of the European Molecular Biology Organisation and a Fellow of the Academy of Medical Sciences.
Francis Crick Institute • London, UK
Leading research on immune cell biology and Down syndrome.
Medical Research Council National Institute for Medical Research • London, UK
Established a research group focusing on signal transduction in lymphocytes.
The Francis Crick Institute does not have traditional 'departments' but operates via interdisciplinary research groups. Candidates apply to the 'Crick PhD Programme' and select specific research topics or labs (e.g., Cell Biology, Immunology, Cancer Research) that align with the listed department names. Students register with one of three partner universities: UCL, King's College London, or Imperial College London.