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Vincent Cryns is a Professor of Medicine and Chief of the Division of Endocrinology, Diabetes, and Metabolism at the University of Wisconsin–Madison. His research focuses on understanding how tumors adapt and survive metabolic stress, with a particular interest in translating insights for improved biomarkers and therapies. His team has developed a novel therapeutic paradigm involving metabolically primed breast tumors using proapoptotic therapy through dietary methionine restriction (MR). The laboratory's studies have demonstrated that dietary MR enhances the antitumor activity of proapoptotic TRAIL receptor agonists by increasing the cell surface expression of TRAIL receptor-2 in tumors. The lab's discoveries have led to clinical trials exploring the metabolic effects of dietary MR in newly diagnosed triple-negative breast cancer (TNBC) patients and its activity in combination with a novel TRAIL agonist in metastatic TNBC. Collaborations with Lamming's lab have shown the metabolic effects of methionine restriction in mice. Overall, his research has demonstrated that MR significantly reduces adiposity and improves glucose homeostasis in murine models of obesity, with ongoing investigations into the mechanisms by which MR inhibits tumor growth and improves metabolic health, as well as the translation of these findings into clinical trials.
Department: Department of Computer Sciences