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J. Wade Harper is the Bert and Natalie Vallee Professor of Molecular Pathology at Harvard Medical School. His research focuses on ubiquitin and ubiquitin-like (UBL) protein conjugation systems, which control a vast array of cellular processes and have significant implications for understanding biological systems. Harper's work employs systematic genetic and proteomic approaches to elucidate the mechanisms governing the biology of ubiquitin and UBL protein conjugation systems, including the autophagy system. He has dedicated efforts to uncover the components and targets of the superfamily of E3 ubiquitin ligases known as cullin-RING ubiquitin ligases. He has explored the roles of these ligases in cell cycle regulation and DNA damage checkpoint control, utilizing advanced proteomic methods. Harper has also investigated the network organization of human deubiquitinating enzymes, as well as their roles in diverse biological processes, including the regulation of mitochondrial assembly. His work is characterized by a strong emphasis on developing proteomic tools and software for quantitative analysis of ubiquitination signaling pathways.
Harvard Medical School • Boston, MA
Leading research on molecular pathology focusing on ubiquitin and UBL proteins.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.