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Walter J. Koch is a Professor in the Department of Surgery at Duke University, specializing in the molecular mechanisms regulating adrenergic signaling in cardiovascular physiology. His research focuses on the roles of G protein-coupled receptor kinases (GRKs) and adrenergic receptors (ARs) in cardiac function and disease. Koch's team utilizes various model systems to study the biochemical and physiological consequences of altered GRK and AR signaling. His laboratory has made significant contributions to the understanding of how modifications in GRK function can impact heart failure and cardiovascular disorders, particularly through the manipulation of GRK levels and AR densities in genetically engineered mouse models. Through innovative gene therapy approaches, he aims to develop new strategies for treating conditions such as heart failure and vascular diseases. Koch's extensive experience and collaborative research efforts continue to advance the field of cardiovascular gene therapy and the understanding of myocardial signaling.
Department of Surgery, Duke University • Durham, NC
Professor in the Department of Surgery specializing in cardiovascular signaling.
Department of Pharmacology & Cancer Biology, Duke University • Durham, NC
Research Professor focusing on cardiac signaling mechanisms.
Department of Biomedical Engineering (MS program)