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Warren Wakarchuk is a Professor in the Faculty of Science at the University of Alberta, specializing in Biological Sciences. His research centers around glycobiology, particularly the structure and function of enzymes involved in the synthesis of glycoconjugates. His lab investigates bacterial enzymes that create cell surface carbohydrate structures mimicking those of hosts, focusing on the corresponding eukaryotic enzymes. He applies enzyme synthesis for the development of bioactive glycoconjugates for therapeutic applications. A significant part of his work involves the creation of designer enzymes for various applications. He is also engaged in synthetic biology within the context of glycobiology, working on enhancing the therapeutic proteins' glycosylation by engineering in vivo protein glycosylation and improving landing sites for glycosyltransferases. The lab studies a natural protein glycosylation system (O-mannosylation) conserved in bacteria, posing fundamental questions about protein modifications in bacteria. By leveraging synthetic biology and glycoproteomics, Wakarchuk aims to address complex problems in this area, hoping to uncover fundamental insights into the role of glycosylation processes in biology.
Department: Mechanical Engineering and Engineering Management