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Wei Guo is the Hirsch Family President's Distinguished Professor at the University of Pennsylvania's Department of Biology, where he focuses on the molecular mechanisms of exocytic trafficking, tumor invasion, and immune suppression. His research primarily investigates the exocyst, an evolutionarily conserved multi-protein complex essential for the targeting and docking of secretory vesicles at the plasma membrane. His work also explores extracellular vesicles (EVs), specifically how they biogenesis is regulated and their role in tumor microenvironments, highlighting the impact of tumor-derived EVs on immune suppression. Guo employs a multidisciplinary approach, integrating biochemistry, biophysics, and cell biology with clinical research, to advance understanding of membrane trafficking processes and their implications in cancer.
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