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Wei Guo is a faculty member at the Perelman School of Medicine, University of Pennsylvania, affiliated with the Graduate Group of Biomedical Graduate Studies. He specializes in cell and molecular biology, focusing on membrane traffic, exocytosis, cell polarity, morphogenesis, the cytoskeleton, and cancer metastasis. Dr. Guo investigates the basic events of exocytosis, which involves the transport, docking, and fusion of secretory vesicles that carry proteins and lipids to the plasma membrane. His research is centered around understanding the molecular basis of exocytosis and the functions of the secretory machinery in concert with the cytoskeleton and small GTP-binding proteins during cell polarization, morphogenesis, and cancer metastasis. The work of his laboratory aims to elucidate the coordination of multiple cellular machines, particularly the exocyst complex, in carrying out important biological functions such as cell migration. By studying both yeast and mammalian cells, Guo aims to uncover fundamental mechanisms of exocytosis and its implications in diseases like cancer and polycystic kidney disease.
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