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Weihan Li is an Assistant Professor in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University. The Li Lab focuses on the molecular understanding of how cells control the spatial organization of gene expression using advanced single-molecule imaging techniques. The lab investigates the precise localization of mRNAs and proteins and how mislocalization can lead to disease. For instance, in yeast, 20% of mRNAs are targeted to the surfaces of the endoplasmic reticulum (ER) and mitochondria, where they are translated to support organelle biogenesis and maintenance. In neurons, mRNAs are transported to synapses, playing essential roles in synaptic activity and learning. Dysregulation of mRNA localization in neurons is associated with neurological disorders, including Fragile X syndrome and amyotrophic lateral sclerosis. The Li Lab employs a combination of cell biology, biochemistry, biophysics, and mathematical modeling to reveal the fundamental principles governing spatial regulation of gene expression and their implications for health and disease. The lab emphasizes a welcoming and collaborative culture, providing personalized mentorship and hands-on training to enhance career prospects in academia and industry.
Albert Einstein College of Medicine • New York, NY
Engaged in advanced research on gene expression and localization in cellular contexts.
Department: Department of Economics