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Weimin Zhang is a Research Assistant Professor at the Institute for Systems Genetics. His research focuses on utilizing synthetic genome technologies to develop advanced human disease models in mice, aimed at improving the understanding of disease mechanisms and accelerating therapeutic discovery. He has pioneered a novel genome rewriting method called mSwAP-In, which enables efficient, scarless, biallelic insertion of large DNA fragments (up to 200 kilobases) into mammalian genomic loci. A key application of the mSwAP-In technique is gene humanization, which allows for the physiological expression of human genes while retaining human-specific alternative splicing in mice. This approach produces next-generation humanized mouse models that accurately mimic human disease, providing a powerful tool for therapeutic development.
Institute for Systems Genetics • New York
Research focused on synthetic genome technologies and human disease models.
Open Program in Biomedical Sciences (Vilcek Institute) covers departments like Biochemistry, Pathology, Neuroscience, Microbiology, etc.