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Wesley Bailis is an Assistant Professor in the Pathology and Laboratory Medicine department at the University of Pennsylvania's Perelman School of Medicine. His research focuses on understanding how metabolism underlies immunological diseases, specifically through the use of CRISPR engineering techniques to study primary human and mouse immune cells. Bailis aims to uncover how spatial compartmentalization of metabolism regulates immune cell states and the potential control of immune signaling by biochemical states. He also investigates inborn errors of metabolism (IEM) and their impacts on the immune system. Collaborating with physicians at Children’s Hospital Philadelphia, he works directly with IEM patients to comprehend the alteration of immune cell functions influenced by metabolism, striving to improve patient care and understanding of immune modulation.
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