Dr. Wesley Wong

Biography

Wesley Philip Wong is an Associate Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard University. His research focuses on understanding the physical basis of biological systems that operate at the nanoscale, with a specific emphasis on the role of mechanical forces. His group investigates how force regulates the structure, dynamics, and interactions of single molecules, and how these factors can affect the functioning and malfunctioning of biological systems. Key research projects include developing novel high-throughput methods for single-molecule manipulation and studying the dynamics of molecular interactions in the circulatory system. His laboratory has made significant contributions to understanding the von Willebrand Factor (vWF), a vascular protein that plays a crucial role in hemostasis. By characterizing the kinetics of vWF using single-molecule force spectroscopy, the Wong lab has demonstrated how hydrodynamic forces impact molecular transitions critical for vascular functionality. He is also engaged in exploring the dynamics of actin-associated proteins and developing therapies based on force-based nanoscale interactions.

Research Interests