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Weston Struwe is an Associate Professor in the Department of Biochemistry at the University of Oxford. His research focuses on understanding the function of viruses by unraveling complex structure-function relationships that influence how viral glycoproteins interact with host receptors and immune cells. Struwe’s work aims to provide structural and biophysical insights that contribute to the development of next-generation therapies for various diseases. His studies emphasize the role of glycan structures in modulating the biological functions of viral glycoproteins, addressing fundamental questions about immune cellular responses during viral infections. Struwe employs advanced techniques such as mass spectrometry and mass photometry to analyze glycoprotein engineering strategies and their implications in infection processes involving viruses like Ebola, Nipah, and HIV-1. In addition to his significant contributions to vaccine design and antibody therapy efficacy, he leverages innovative methodologies to overcome the challenges posed by the structural biology of glycoproteins. His goal is to elucidate the mechanisms of antibody-mediated neutralization and receptor binding cooperativity within the context of viral fitness and host interactions. Struwe's lab is at the forefront of research dedicated to tracking viral glycoprotein interactomes, thereby advancing the understanding of viruses' roles in human health and disease.
Department of Politics and International Relations - Higher Level English requirement.