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Willem Stoorvogel is a professor at Utrecht University, specializing in cellular biology. With over 20 years of experience, his research group investigates the general molecular mechanisms that regulate endosome dynamics and the sorting of organelles involved in the transport of medically relevant cargo molecules, particularly focusing on MHC class II molecules in professional antigen presenting cells. His team is examining how newly synthesized MHC class II molecules are loaded into endosomal compartments with antigen-derived peptides, which are then presented on the cell surface. A significant component of their current research involves studying the roles of MHC class II incorporated into exosomes, which are small vesicles generated and secreted by endosomes, in the immunological context. Moreover, Stoorvogel's research also focuses on the role of prostasomes, which are prostate epithelial cell-derived exosomes found in semen, within immune responses.
Department of Psychology